Using the Mini Modbus board with Mach3. Make sure you select the correct COM port as well as the baudrate you have set on the Mini MODBUS board, the default is 57600, then click. (0 in this case) and select the Serial Plugin Enabled radio button.

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Just a double check here as I'm wondering if you guys are talking at cross purposes. If by 'programable control' you mean can Mach drive the AXES of a machine in a cordinated manner via RS232 as it does via the parallel port then the answer is pretty much as Terry has indicated. Of course this is basically what a USB smoothstepper and it's ilk do except it's via USB of course rather than RS232.

However - if by 'programable control' you mean sending control signals to 'an external' machine to do other 'stuff' like control valves or turn things on/off, send/receive data etc. Then of course the answer is yes - Mach can do that. If this IS what you're wanting then your choices are direct serial control or Modbus RTU.